Decreased vascular and increased adrenal and renal sensitivity to angiotensin II in the newborn lamb.

Decreased vascular and increased adrenal and renal sensitivity to angiotensin II in the newborn lamb.

The effects of two doses of angiotensin II (0.025 micrograms/kg per min and 0.25 micrograms/kg per min) on plasma renin activity (PRA), aldosterone concentration, creatinine clearance, and sodium and potassium excretion were studied in two groups of 2- to 3-week-old lambs. The 0.025 micrograms/kg per min dose of angiotensin II also was studied in six adult ewes. In response to the angiotensin I...

Increased vascular sensitivity to angiotensin ii in psychosocial hypertensive mice.

CBA mice develop hypertension when placed in complex population cages that facilitate social interactions and competition for territory. After 1 month, these mice have normal plasma renin levels, but blockade of converting enzyme lowers blood pressure to normal. To test the possibility that this normal-renin hypertension is caused by enhanced pressor responsiveness to angiotensin II (AII), we e...

Rapid modulation of renal and adrenal responsiveness to angiotensin II.

Reciprocal changes in adrenal and vascular responsiveness to angiotensin II (Ang II) are part of the normal adaptation to shifts in salt intake. When dietary salt intake is abruptly reduced from high to low, enhancement in aldosterone secretion requires several days to develop. Once established it is not known how quickly the enhancement is reversed with salt repletion. We investigated the time...

Adrenal angiotensin II receptors and vascular reactivity to angiotensin II in the rat during continuous inhibition of angiotensin converting enzyme.

1. The effect of continuous infusion of captopril (80 microgram/h) for up to 5 days on blood pressure, adrenal angiotensin II receptors and vascular reactivity exogenous angiotensin II, arginine vasopressin and noradrenaline was studied in the rat. 2. In treated rats, blood pressure decreased transiently to a minimum after 2 days (-18 mmHg). Vascular reactivity to angiotensin II, but not to arg...

Increased renal vascular reactivity to angiotensin II after unilateral nephrectomy in the rat involves 20-HETE